Effects and mechanisms of low carbohydrate and low GI diet on postprandial glucose and lipid metabolism in adults

Study on the effect and mechanism of low-carbohydrate and low-GI dietary pattern on postprandial glucose and lipid metabolism in adults by regulating intestinal microbiota and improving cholesterol metabolism

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400093484

Enrollment

Unknown

Registered

2024-12-05

Start date

2024-09-30

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

High-carbohydrate high-GI diet group:Carbohydrates account for 65% of energy, GI>70.

High-carbohydrate low-GI diet group:Carbohydrates account for 65% of energy, GI70.

Low-carbohydrate low-GI diet group:Carbohydrates account for 45% of energy, GI<55.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Men and women aged 18-65 years; 2.BMI 22 to 35 kg/m?2; 3.Agree to be randomly assigned to intervention group or control group; 4.Be willing to consume the food and drink provided by the study.

Exclusion criteria

Exclusion criteria: 1.Age 65 years; 2.BMI 35 kg/m?2; 3.Taking medications that affect cholesterol metabolism or blood glucose metabolism; 4.Participating in a weight loss program; 5.Vegetarian; 6.Taking probiotics, multivitamins, fish oils, herbal supplements, or supplements containing dietary fiber within 30 days before and during the study and unwilling to stop taking it; 7.Drinking more than twice a day and can not stop drinking in the research process; 8.Having food allergies or other problems that may affect food intake; 9.Using NSAIDs or antihistamines and unable to stop using these drugs within 72 hours prior to study; 10.Taking hormonal drugs such as anticoagulants, anabolic steroids, hydrocortisone; 11.Patients with chronic metabolic diseases (including cardiovascular disease, diabetes, kidney, thyroid, gastrointestinal and liver diseases, etc.); 12.Existing untreated hypertension; 13.Smoking in the past 12 months; 14.Poor venous access; 15.Self-reported weight gain or loss of more than 7 kg in the 6 months before enrollment; 16.Unwilling to maintain weight throughout the study period; 17.Unable to consume only the food and drink provided during the study.

Design outcomes

Primary

Measure	Time frame
Blood glucose level;Blood lipid profile;	—

Secondary

Measure	Time frame
Serum insulin level;Hormones of the gastrointestinal tract level;Concentration of non-esterified fatty acids;	—

Countries

China

Contacts

Public ContactHuicui Meng

School of Public Health(Shenzhen), Sun Yat-sen University

menghc@mail.sysu.edu.cn+86 157 6899 2680

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026