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Prognostic effect of early use of sacubitril/valsaltan in patients with myocardial infarction complication:a retrospective comparative study

Factors related to acute myocardial infarction complicated by mitral regurgitation and the use of sacubitril-valsartan

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400093478
Enrollment
Unknown
Registered
2024-12-05
Start date
2022-07-01
Completion date
Unknown
Last updated
2024-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute myocardial infarction

Interventions

Sacubitril/valsartan Group:none
Benazepril Group:none

Sponsors

Qinhuangdao First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Patients with first acute myocardial infarction should undergo coronary intervention or conservative drug treatment; (2) Cardiac ultrasound examination within one week of hospitalization showed that myocardial segmental movement abnormalities, mitral regurgitation (mild, moderate or severe) ; (3) ejection fraction greater than or equal to 40%

Exclusion criteria

Exclusion criteria: (1) History of valvular heart disease; (2) Previous physical examination or cardiac ultrasound showed mitral regurgitation; (3) History of acute and chronic heart failure, history of cardiac surgery; (3) various cardiomyopathies; (4) persistent or permanent atrial fibrillation; (5) Death during hospitalization for the first acute myocardial infarction; (6) Severe liver and kidney insufficiency, severe anemia, severe respiratory failure; (7) Advanced malignant tumors.

Design outcomes

Primary

MeasureTime frame
Major adverse cardiovascular events (MACE);Mitral regurgitation volume(MRV);Left ventricular ejection fraction(LVEF);N-terminal pro-brain natriuretic peptide (NT-proBNP);Left ventricular end-diastolic volume (LVEDV);

Countries

China

Contacts

Public ContactHongtao Yin

Qinhuangdao First Hospital

yinhongtao0627@163.com+86 181 3350 9982

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026