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High fidelity and sensitive detection of single extracellular vesicle nucleic acid based on novel DNA nanoprobes Research on Methods and Their Response Mechanisms

High fidelity and sensitive detection of single extracellular vesicle nucleic acid based on novel DNA nanoprobes Research on Methods and Their Response Mechanisms

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400093474
Enrollment
Unknown
Registered
2024-12-05
Start date
2025-01-01
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer

Interventions

Gold Standard:Pathology
Index test:EV-miRNA

Sponsors

Southern Medical University Southern Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patient inclusion criteria: age = 18, male or female; Voluntarily signed informed consent; Patients diagnosed with breast cancer by the Guidelines and Norms for the Diagnosis and Treatment of Breast Cancer of the Chinese Anti-Cancer Association (2024 Edition); First onset; Not receiving chemoradiotherapy or surgery; No mental illness and can understand communication normally. 2. Inclusion criteria for healthy volunteers: age = 18, male or female; Voluntarily signed informed consent; Imaging tests have been done; Normal individuals diagnosed with no underlying diseases and tumors in Nanfang Hospital, that is, normal liver function, normal electrocardiogram, normal tumor markers and blood routine tests.

Exclusion criteria

Exclusion criteria: 1. Patient exclusion criteria: extensive systemic metastasis of the tumor; Combined tumors at other sites; Severe organ dysfunction; Estimated survival < 3 months; pregnant women; Cases in which the data of the subjects are incomplete, or the collection is incomplete for other reasons; It is judged by the investigator to be unsuitable for participation in this study. 2. Exclusion criteria for healthy volunteers: cases with incomplete subject information or incomplete collection for other reasons; pregnant women; It is judged by the investigator to be unsuitable for participation in this study.

Design outcomes

Primary

MeasureTime frame
EV-miRNA;

Countries

China

Contacts

Public ContactYe Zhang

Southern Medical University Southern Hospital

Zhangye232@i.smu.edu.cn+86 15622126037

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026