lupus nephritis
Conditions
Interventions
experimental group:Fecal MicrobiotaTransplantation
Sponsors
The First Medical Center, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age 18-70 years; Diagnosis in accordance with the diagnostic classification criteria for systemic lupus erythematosus (SLE) published jointly by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) in 2019; Renal biopsy diagnosis of lupus nephritis; 24-hour urine protein quantification >0.5g; Anti-double-stranded DNA >= 77 IU/mL (ELISA) or >= 20 IU/mL (Farr) or complement C3 < 1.4 g/L, C4 < 0.4 g/L; Voluntarily accepting fecal microecological product transplantation therapy.
Exclusion criteria
Exclusion criteria: Malignant tumors; History of neuropsychiatric disorders and alcohol abuse; Patients who have used antibiotics within the last 1 week; Pregnant and lactating women; Concomitant serious diseases of other systems, such as severe hepatic insufficiency and cardiac insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour urine protein;blood albumin;glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions and grading;blood creatinine;blood urea;C-reactive protein;Systemic Lupus Erythematosus Disease Activity Index (SLEDAI);The structural and quantity alterations of intestinal flora before and after fecal transplantation; | — |
Countries
China
Contacts
Public ContactYang Yunsheng
The First Medical Center, Chinese PLA General Hospital
Outcome results
None listed