osteoarthritis (OA)
Conditions
Interventions
Healthy control group:N/A
OA Early Group:N/A
OA Late Stage Group:N/A
Sponsors
The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei)
Eligibility
Sex/Gender
All
Age
40 Years to 89 Years
Inclusion criteria
Inclusion criteria: A total of 80 individuals ranging in age from 40 to 89 years were enrolled in this study (comprising 40 patients with early osteoarthritis and 40 patients with late osteoarthritis). All knee OA patients fulfilled the criteria established by the American College of Rheumatology (ACR) and were verified through a comprehensive medical history and examination. They were further classified by two independent orthopedic and radiology physicians using X-ray or MR images, the Kellgren and Lawrence scoring system, and clinical manifestations as either early (undergoing conservative treatment) or late (scheduled for total knee replacement). The physicians were oblivious to the patients' conditions. All eligible and consenting individuals were recruited. Forty age- and sex-matched healthy volunteers who underwent annual routine medical evaluations at a health check-up center and were clinically screened to confirm the absence of any significant joint or spinal OA were enlisted as the healthy control group for this study. All participants had not received radiation therapy, chemotherapy, targeted therapy, or other immunotherapy; their past medical history, current medical history, personal history, postoperative pathology, and environmental data were complete, and they voluntarily signed an informed consent form.
Exclusion criteria
Exclusion criteria: In case of being diagnosed with other types of musculoskeletal disorders such as osteomyelitis and peripheral nerve injury, or other types of injuries to the musculoskeletal system, like rheumatoid arthritis, gouty arthritis, and traumatic arthritis; having a history of other types of joint diseases in different locations, such as rheumatoid arthritis, gouty arthritis, and traumatic arthritis; having a history of anterior cruciate ligament resection; having a history of knee injury; having a history of other rheumatological and immunological disorders such as ankylosing spondylitis, scleroderma, and Sjogren's syndrome; having a history of previous treatment with radiation therapy, chemotherapy, targeted therapy, and other immunotherapies; refusal to sign an informed consent form; abnormal liver and kidney functions; having a history of neurological disorders, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Retinol-binding protein 4; | — |
Secondary
| Measure | Time frame |
|---|---|
| The levels of diverse biomarkers; | — |
Countries
China
Contacts
Public ContactRende Ning
The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei)
Outcome results
None listed