Gynecological diseases
Conditions
Interventions
Hydromorphone mixed with isobaric bupivacaine group (HB group):Introduce 25 G puncture needle into the subarachnoid space between L2-3 and L3-4 in a standard aseptic way, and confirm whether the punct
Simple Isobaric Bupivacaine Group (Group B):Introduce 25 G puncture needle into the subarachnoid space between L2-3 and L3-4 in a standard aseptic way, and confirm whether the puncture is in place by
Sponsors
Xing'an League People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The age is over 18 and under 65. American Society of Anesthesiologists (ASA) grades I ~ II; The results of B-ultrasound examination on admission are in line with the clinical diagnostic criteria of pelvic tumor in Obstetrics and Gynecology. Patients have indications for open surgery; No contraindication of spinal anesthesia; Patients and their families know and sign the informed consent form of this study.
Exclusion criteria
Exclusion criteria: Coagulation dysfunction; Past allergic history of hydromorphone, bupivacaine and NSAIDs; Communication barriers such as mental illness and different languages; Not cooperating to complete the puncture in spinal canal; History of paresthesia of lower limbs or peripheral nerve diseases; Those who had opioid addiction, allergy and contraindications in the past;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) scores were obtained at 6 h, 12 h, 24 h and 48 h after operation.;The number of self-controlled analgesic compressions and the cumulative amount of opioids used 48 hours after operation;Postoperative adverse reactions were recorded, including nausea, vomiting, dizziness, delirium or disorientation.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of vascular complications in operation center (incidence rate of arrhythmia, application rate of antihypertensive drugs, application rate of antihypertensive drugs);Basic information during operation (blood pressure, heart rate, body temperature);Dosage of vasoactive drugs during operation (ephedrine, norepinephrine, atropine, urapidil, esmolol, etc.);Intraoperative infusion volume, bleeding volume and urine volume;Intraoperative complications (arrhythmia, myocardial infarction, cardiac arrest, hypoxemia, allergy, etc.);The dosage of opioids 48 hours after operation;Incidence rate of postoperative cardiovascular complications;Postoperative hospitalization days; | — |
Countries
China
Contacts
Public ContactMa Yuhua
Xing'an League People's Hospital
Outcome results
None listed