Liver Diseases
Conditions
Interventions
Ciprofol group:Intravenous pumping of ciprofol during maintenance of anesthesia
Sevoflurane group:Inhaled sevoflurane during anesthesia maintenance
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subjects scheduled for partial hepatectomy; 2. Age 18 to 65 years old, gender is not limited; 3. American Society of Anesthesiologists (ASA) class I, II, III; 4. Body mass index (BMI) of 18-28 kg/m^2 ; 5. The patient's cognitive status is good; 6. Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with Child-Pugh score grading B or C, hepatic encephalopathy, ascites or ruptured varices of the esophagogastric fundus with bleeding, prothrombin time >16 seconds, International Normalized Ratio (INR) >1.5, Activated Partial Thromboplastin Time (APTT) >36 seconds, Prothrombin Time (PT) >18 seconds, Platelet Count (PC) <100*10^9/L; 2.Patients with severe organ dysfunction such as heart, lung, brain, kidney and other severe pathologies; 3.Patients with cognitive impairment or history of psychiatric disorders, etc., who are unable to cooperate with the investigators; 4.Long-term use of sedative or analgesic drugs, opioid dependence or tolerance, and history of drug abuse; 5.History of allergy or contraindication to the anesthetic drugs used; 6.Have motion sickness or previous history of postoperative nausea and vomiting (PONV); 7.Patients who have been determined to have difficulty with airway management; 8.Any other condition that, in the opinion of the investigator, makes participation in this trial inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the level of Alanine aminotransferase in serum;the level ofAspartate aminotransferase in serum;Total serum protein level;Serum albumin levelxue;Serum total bilirubin level;Dosage of perioperative vasoactive drugs;Perioperative Adverse Time Occurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative hemodynamic ;Indicators for monitoring depth of perioperative anesthesia (EEG bispectral index);Dosage of perioperative anesthetic drugs;Serum inflammatory markers (interleukin 6, tumor necrosis factor alpha);Quality of recovery three days after surgery (qor-15 scale score); | — |
Countries
China
Contacts
Public ContactHui Luo
Xiangya Hospital Central South University
Outcome results
None listed