FindTrial
Sign In

The research on the Neuroinflammation and Brain Network Mechanisms of Postoperative Cognitive Dysfunction Based on Multimode Magnetic Resonance Imaging

Study on the Neuroinflammation and Brain Network Mechanisms of Postoperative Cognitive Dysfunction Based on Multimodal Magnetic Resonance Imaging

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400093448
Enrollment
Unknown
Registered
2024-12-05
Start date
2024-12-31
Completion date
Unknown
Last updated
2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Cognitive Dysfunction

Interventions

Cardiac valve replacement group:None
Healthy control group:None

Sponsors

Xuzhou Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Cardiac surgery patients supported by cardiopulmonary bypass; 2.Age >=18 years; 3.Simple Mental State Examination Scale (MMSE) score >=23.

Exclusion criteria

Exclusion criteria: 1.With magnetic metal implants; 2.Neuropsychiatric disorders; 3.Dysfunction of vital organs such as liver and kidneys; 4.Visual, auditory, and speech impairments.

Design outcomes

Primary

MeasureTime frame
Cognitive function;Dynamic functional connectivity between hippocampus and medial prefrontal cortex; The change characteristics of Brain functional networks;—

Secondary

MeasureTime frame
Systematic inflammatory response;Brain metabolism and neuroinflammation;—

Countries

China

Contacts

Public ContactYangzi Zhu

Xuzhou Central Hospital

zhuyz@188.com+86 181 6877 9150

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026