Sepsis
Conditions
Interventions
The landiolol group:Besides standard treatment for sepsis, participants randomised to this arm will receive landiolol. The continuous intravenous infusion of landiolol was started at 1.0 µg/kg/min, in
The standard group:Participants randomised to this arm will receive standard care only for sepsis but not receive any beta blockade for the duration of their ICU stay. If the treating clinician deems
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Infection was present and SOFA score >=2 points 2.Receiving adequate fluid resuscitation to reach central venous pressure of 8-12 mmHg,and to maintain a target blood pressure at 65 mmHg or higher ,and heart rate >=100 bpm ( at the time of randomisation); 3.Performing invasive hemodynamic monitoring; 4.Expecting the length of ICU stay is greater than 48 hours; 5.Aged 18 years or above .
Exclusion criteria
Exclusion criteria: 1.Having been treated with ß blockers within one month prior to admission; 2.Having pre-existing severe cardiac dysfunction (NYHA grade 3 or more) ,heart block and tachyarrhythmia; 3.Factors affecting the results of NIRS monitoring include surgery involving frontal lobe lesions, frontal contusion and laceration, bilateral frontal scalp hematoma, decompressive craniotomy, subdural or epidural hematoma, effusion, gas, cerebral hemorrhage, tumor, intracranial infection, and cerebral ischemia; 4.Pregnant woman.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral oxygenation index,COX; | — |
Secondary
| Measure | Time frame |
|---|---|
| Regional cerebral oxygen saturation, rSO2;Peak systolic velocity of the middle cerebral artery;End diastolic velocity of the middle cerebral artery;Mean velocity of the middle cerebral artery;Resistance index of the middle cerebral artery;Pulsatility index of the middle cerebral artery;Picco/Vigileo hemodynamic parameter;Inflammatory mediator indicators;Inflammatory response indicators;The Confusion Assessment Method-Intensive Care Unit,CAM-ICU;The Glasgow Coma Scale,GCS;28-Day Mortality; | — |
Countries
China
Contacts
Public ContactBaochun Zhou
The Second Affiliated Hospital of Soochow University
Outcome results
None listed