Postoperative gastrointestinal dysfunction
Conditions
Interventions
Ciprofol group:General anesthesia induction and maintain with ciprofol
Propofol group:General anesthesia induction and maintain with propofol
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old; 2. BMI is 18~30kg/^2; 3. Planned laparoscopic radical colorectal cancer surgery; 4. NYHA cardiac function grade I-II; 5. ASA grading I-III; 6. Patients and their families understand this study, voluntarily participate in this trial, and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of allergy to the drugs used; 2. Current and long-term use of analgesics, psychotropic drugs, hormones, drugs affecting gastrointestinal motility (morpholine, mosapride, M1 receptor agonist/inhibitor, etc.) or non-steroidal anti-inflammatory drugs; 3. Respiratory insufficiency, presence of difficult airway or judged to be difficult to endotracheal intubation (modified Mahaloban score of grade III. or IV); 4. Patients with severe organic diseases, organ dysfunction or electrolyte disorders. 5. Patients with previous mental and neurological diseases: such as depression, Parkinson's disease, basal gangliopathy, schizophrenia, epilepsy, Alzheimer's disease, myasthenia gravis, cerebrovascular accident, etc.; 6. Patients who are considered by the investigator to be inappropriate to participate in the trial; 7. Participation in another study within 4 weeks prior to the current trial; 8. Patients with drug and alcohol abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative gastrointestinal intolerance;Hospitalization costs;First meal intake time after surgery;Incidence of postoperative gastrointestinal dysfunction;First defecate time after surgery;Postoperative hospital length of stay;Hemodynamic suppression:(1) incidence of hypotension;(2) incidence of sinus bradycardia; | — |
Countries
China
Contacts
Public ContactYaomin Zhu
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed