None
Conditions
Interventions
one:The modified Dixon sequential method was used to conduct the trial, and the initial dose of oliceridine was set at 15 ug/kg, and the serial dose was 1.5 ug/kg. If the examination does not meet the
Otherwise, if it is negative, the next patient is reduced by 1 dose gradient, and the study is terminated when 7 crossovers occur (positive to negative).
Sponsors
Deyang People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients scheduled for painless gastroscopy; American Society of Anesthesiologists (ASA) class I-II; Aged 18~64 years old; Body mass index (BMI) 18~27 kg/m2;
Exclusion criteria
Exclusion criteria: difficult airway (modified Marhalanobis score grade IV.); poorly controlled hypertension (SBP>=160 mmHg and/or DBP>=100 mmHg); History of chronic use of anticonvulsant, sedative/alcohol, or opioid abuse; Mental disorders that are unable to express themselves properly; History of allergies to the drugs involved in the study, asthma attack period; Known or suspected gastrointestinal obstruction; Pregnancy or lactation; Combined with severe cardiovascular, renal and liver diseases;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocelidine dosage and effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Mean arterial pressure;oxygen saturation;patient satisfaction score and operator satisfaction score;Occurrence of complications;Sedation success rate;Gastroscopy operation time;Anesthesia recovery time;Time of patient discharge (The time the patient was sent out of the PACU); | — |
Countries
China
Contacts
Public ContactXianjie Zhang
Deyang People’s Hospital
Outcome results
None listed