Respiratory failure
Conditions
Interventions
P0 (Propofol 2mg/kg dose group):Propofol 2mg/kg induces sedation with tracheal intubation
R1 (Rimazolen benzenesulfonate 0.2mg/kg dose group):Induction of sedative tracheal intubation with 0.2 mg/kg Remimazolam besylate
R2 (Rimazolen benzenesulfonate 0.3mg/kg dose group):Induction of sedative tracheal intubation with 0.3 mg/kg Remimazolam besylate
R3 (Rimazolen benzenesulfonate 0.4mg/kg dose group):Induction of sedative tracheal intubation with 0.4 mg/kg Remimazolam besylate
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age range from 18 to 80 years old, gender not limited; 2.BMI 18~ 30 kg /m^2; 3.The emergency department requires endotracheal intubation and sedation treatment; 4.Obtain informed consent from patients or their families.
Exclusion criteria
Exclusion criteria: 1. Those who are known or suspected to be allergic or contraindicated to various components of the experimental drugs involved in the research; 2.Individuals with a known history of severe mental illness; 3.Patients whose blood pressure cannot be maintained to systolic blood pressure >= 90mmHg and MAP >= 65mmHg before intubation induction; 4. Coma patients; 5. Patients with myasthenia gravis; 6. Pregnant and lactating women; 7. Individuals who have experienced tracheotomy, difficult intubation, or airway stenosis; 8.Alcoholism or long-term use of nonsteroidal drugs, analgesics, and sedatives; 9. Other situations deemed unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypotension within 10 minutes after intubation (Hypotension is defined as systolic blood pressure20% within 10 minutes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;heart rate;Oxygen saturation;Respiratory rate;Induction time;Intubation time;Awake time;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactShirong Lin
The first affiliated hostipal of nanchang university
Outcome results
None listed