Spinal Correction
Conditions
Interventions
The Oxalidine group:Oxalidine fumarate, 1.5mg/1.5ml, was drawn into a 5-ml syringe by the study coordinator and diluted to 5ml with 0.9% sodium chloride injection, which was delivered to the PACU anes
Fentanyl group:Fentanyl citrate injection 0.05mg was diluted to 5ml with 0.9% sodium chloride injection, drawn into a 5ml syringe by the study coordinator, and handed to the PACU anesthesiologist for
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, =4 in POstanesthesia care unit; Postoperative patient-controlled intravenous analgesia (PCIA) was used; 6. Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in the study; 2. Patients with sick sinus syndrome, severe sinus bradycardia (heart rate =III; Abnormal electrocardiography (QTcF interval >450 msec for men and >470 msec for women at screening); 3. Patients with preoperative diagnosis of sleep apnea, or STOP-Bang score (Appendix 1) >=3 and HCO3->=28mmol/L; 4. History of hyperthyroidism and pheochromocytoma before surgery; 5. Preoperative schizophrenia, epilepsy, myasthenia gravis and delirium; 6. Severe liver dysfunction (Child-Pugh class C, Annex 2); Severe renal dysfunction (dialysis before operation); ASA grade >=IV; 7. Cannot understand the visual analogue scale or has language communication difficulties; 8. History of opioid allergy; 9. Long-term opioid use (defined as >15 morphine equivalent units/day, > 3 days/week for >1 month within 1 year after surgery); 10. Long-term treatment with non-steroidal anti-inflammatory drugs (NSAID used for >2 weeks daily within 6 months before surgery); 11. Body weight 35kg/m2; 12. Other circumstances deemed inappropriate by the investigator or physician in charge.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in pain scores was changed half an hour after the experimental drug was given; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score and opioid consumption (PIOC) score at 72 hours;Incidence of POGD 3 days after surgery;The incidence of moderate to severe pain within 72 hours after surgery;NRS was used to evaluate pain at rest and during activity within 3 days after surgery;Total opioid consumption within 3 postoperative days;Quality of postoperative recovery;Cumulative analgesic consumption and rescue analgesic administration within 3 days after surgery;RASS score at each time point within 5 days after surgery;Incidence of delirium within 5 days after surgery;NRS score during the first 5 postoperative nights;Postoperative gastrointestinal function recovery indicators included time to first exhaust, time to first bowel sounds and time to first defecation;Length of postoperative hospital stay;Total duration of analgesia within 30 days after surgery;The incidence of complications (including all-cause death) within 30 days after surgery was analyzed;Pain, quality of life, and orthopedic condition were evaluated 90 days after surgery; | — |
Countries
China
Contacts
Public ContactJinhua Bo
Nanjing Drum Tower Hospital
Outcome results
None listed