PFAPA syndrome (Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome)
Conditions
Interventions
Probiotic group:Daily oral intake of probiotics (containing 1×10^8 live Lactobacillus reuteri DSM17938 and 1×10^9 live Bifidobacterium longum BB536)
placebo group:Daily oral administration of placebo sunflower seed oil.
Sponsors
The Second Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
2 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. PFAPA patients: Age =12 years and =2 years;.fever episodes =3 times, lasting up to 5 days, with a regular interval, and fever resolves within a few hours after administration of corticosteroids; pharyngitis with adenitis or stomatitis; good health between episodes and normal growth; acute phase reactants (e.g., C-reactive protein, ESR) are elevated during fever episodes but not during inter-episode periods. Neutropenia or other atypical symptoms (e.g., cough, nasal discharge, severe abdominal pain, diarrhea, severe vomiting, rash, arthritis, or neurological dysfunction) should be excluded. 2. Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Other periodic fever diseases, patients with rheumatoid arthritis complicated by infection, tumor, or other autoimmune diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of onset;Frequency of onset; | — |
Countries
China
Contacts
Public ContactWenjie Zheng
The Second Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed