Parkinson's disease
Conditions
Interventions
active stimulation group:Transcranial direct current stimulation combined with conventional cognitive training
sham stimulation group:sham transcranial direct current stimulation combined with conventional cognitive training
Sponsors
Nantong First People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 40 and 85, gender not limited; 2.Meeting the diagnostic criteria for primary Parkinson's disease according to the Chinese Parkinson's Disease Guidelines (2016 edition); 3.The types and doses of anti-Parkinson's disease medications remain unchanged during the intervention period; 4.Hoehn-Yahr staging: I-III; 5.Mini-Mental State Examination (MMSE) score between 15 and 26, with no language communication barriers and capable of completing assessments; 6.Consent and sign the informed consent form to participate in this study.
Exclusion criteria
Exclusion criteria: 1.Secondary Parkinson's syndrome or Parkinson's plus syndrome caused by various factors; 2.Essential tremor, primary dystonia, and other diseases; 3.Individuals with severe cardiopulmonary diseases and hepatorenal dysfunction; 4.Patients with other diseases that may affect training (such as visual or auditory impairments, severe physical activity limitations, contraindications for exercise, or other factors that prevent cooperation in completing the trial); 5.Patients whose PD-related comorbid symptoms are considered by the clinician to significantly affect cognitive function testing; 6.Those currently undergoing other non-pharmacological interventions; 7.Individuals with implanted cardiac pacemakers, those who cannot remove various metal devices, those with metal clips left in the body after surgery, and those with claustrophobia or other conditions that prevent MRI examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| auditory verbal learning test—Huashan version score;trail making test score;symbol digit modalities test score;Hamilton Depression Scale Score;Hamilton Anxiety Scale Score;the level of GABA in the cerebellum; | — |
Countries
China
Contacts
Public ContactChen weiguan
Nantong First People's Hospital
Outcome results
None listed