None
Conditions
Interventions
C group:Opioids
OFA group:Non-opioid+nerve block
Sponsors
The Second Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patient or legal representative signs the informed consent; 2. The first total hip replacement under elective general anesthesia is planned ; 3.Age 65-80 years old; 4, ASAI-III level; BMI 20-30?/?.
Exclusion criteria
Exclusion criteria: 1. Allergy to the drugs used in this study; 2. Opioid addiction or dependence; 3, Severe bradycardia and atrioventricular block; 4.Contraindications to the use of esketamine; 5. Previously known neuromuscular diseases;6.Severe liver and kidney dysfunction; 7.Previous history of mental illness; 8. Preoperative cognitive dysfunction;9 Contraindications of nerve block operation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of Qor-15 scale 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Score of Qor-15 scale 48 hours after surgery;Score of Qor-15 scale 72 hours after surgery;Hemodynamic indexes during the surgery;Extubation time;Sufentanil consumption 24 hours after surgery;Sufentanil consumption 48 hours after surgery;Incidence of postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactMingjian Kong
The Second Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed