Study on the effect of probiotics in improving post-stroke depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400093354

Enrollment

Unknown

Registered

2024-12-03

Start date

2022-06-01

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke depression

Interventions

Experimental group:Citalopram+Probiotic yogurt

Control group:Citalopram

Eligibility

Sex/Gender

All

Age

33 Years to 78 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria for PSD in the 2019 Chinese Expert Consensus; (2) Have normal behavioral cognitive ability and can communicate normally; (3) Mild to moderate stroke patients with NIHSS score <=20; (4) Patients with mild to moderate depression assessed by HAMD scale; (5) Voluntarily participate in this study and sign the informed consent.

Exclusion criteria

Exclusion criteria: (1) Patients who have used (intravenous or oral) antibacterial drugs within the past month; (2) Patients with severe metabolic syndrome; (3) inflammation or lesions of the liver or intestine; (4) Patients with tumor, HIV or unstable vital signs; (5) Unable to cooperate with researchers to complete the whole process

Design outcomes

Primary

Measure	Time frame
Fecal flora;	—

Secondary

Measure	Time frame
Inflammatory factor level;	—

Countries

China

Contacts

Public ContactZhi Qi

Third Hospital of the Naval Medical University

790961222@qq.com+86 158 0098 9597

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026