Ventilator associated pneumonia
Conditions
Interventions
Tobramycin group:Tobramycin inhalation solution, nebulized inhalation, 300mg (5ml)/time, 2 times/day, continuous for 6 doses.
Placebo group:0.9% sodium chloride solution, nebulized inhalation, 5ml/time, 2 times/day, continuous for 6 doses.
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18; 2. Adult patients undergone invasive mechanical ventilation for at least 72 hours. 3. Written informed consent from the patient or their representative;
Exclusion criteria
Exclusion criteria: 1. Suspected or confirmed ventilator-associated pneumonia; 2. Receiving systemic aminoglycoside therapy; 3. Acute kidney injury classified as stage 2 or 3 according to the KDIGO (Kidney Disease: Improving Global Outcomes) criteria; 4. Chronic kidney disease (GFR 96h of invasive mechanical ventilation; 7. Patients with tracheostomy tube; 8. Be allergic to aminoglycoside antibiotics; 9. Myasthenia gravis; 10. Pregnant or breastfeeding women; 11. Any interventional or VAP-related clinical study conducted within 30 days prior to recruitment; 12. Other patients considered by the researchers to be unsuitable for inclusion in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| First episode of ventilator-associated pneumonia from randomization to day 28.; | — |
Secondary
| Measure | Time frame |
|---|---|
| First episode of ventilator-associated pneumonia from randomization to day 7;the incidence of ventilator-associated pneumonia caused by tobramycin-sensitive Gram-negative bacteria from randomization to day 28;The number of systemic antibiotics used day from randomization to day 28;the number of days with administration of at least one systemic antibiotic from randomization to Day 28;First episode day of ventilator-associated pneumonia from randomization to day 28.;Total days without mechanical ventilation from randomization to day 28;Hospital death and ICU death from randomization to Day 28;the number of days in the ICU and the hospital from randomization; | — |
Countries
China
Contacts
Public ContactBin He
Shanghai Chest Hospital
Outcome results
None listed