Pain after Total Knee Arthroplasty
Conditions
Interventions
Experimental Group:Postoperative adductor canal block with 133mg(20ml) liposomal bupivacaine at affected limb
Control group:Postoperative adductor canal block with 80mg(20ml) ropivacaine at affected limb
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients planning to undergo unilateral total knee arthroplasty. 2.Age >= 18 years old.
Exclusion criteria
Exclusion criteria: 1. Patients with neurological or mental diseases that may affect pain or cognitive function (such as Alzheimer's disease, schizophrenia, depression, trigeminal neuralgia, painful diabetes peripheral neuropathy, post herpetic neuralgia, etc.); 2. Patients with severe systemic diseases (such as heart failure, myocardial infarction, cerebrovascular infarction, chronic kidney disease, severe connective tissue disease, active peptic ulcer disease, malignant tumors, etc.); 3. Patients who regularly use glucocorticoids or opioid drugs (such as morphine, fentanyl, hydromorphone, ketobemide, methadone, nicomorphine, oxycodone, or pethidine, etc.); 4. Patients who are allergic to local anesthetic drugs such as bupivacaine and ropivacaine; 5. The ipsilateral knee joint has undergone surgery (such as total knee arthroplasty, knee single condyle arthroplasty, arthroscopic surgery, fracture open reduction and internal fixation surgery, etc.) or has undergone surgery on other parts within the past 3 months; 6. Patients diagnosed with rheumatoid arthritis; 7. Patients with Glycated Hemoglobin (HbA1c)>8%; 8. Patients with severe osteoporosis; 9. The researchers believe that patients are unlikely to comply with the trial requirements after randomization; 10. The patient is receiving the investigational drug as part of another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) score after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps muscle strength;Knee joint range of motion;Knee joint function score;Postoperative morphine consumption;Perioperative adverse reactions (nausea, vomiting, fever, pruritus, constipation); | — |
Countries
China
Contacts
Public ContactDeng Zhantao
Guangdong Provincial People's Hospital
Outcome results
None listed