Adolescent Obsessive-Compulsive Disorder
Conditions
Interventions
Adolescent Obsessive-Compulsive Disorder Patient Group:None
Healthy Control Group:None
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: Patient Group: (1) Meets the DSM-5 diagnostic criteria for OCD; (2) Age between 10 to 18 years old; (3) Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) score of 16 or above; (4) Patients voluntarily participate in the study, with the consent of their family members, and have signed an informed consent form; (5) Capable of understanding written language and able to complete questionnaires. Healthy Control Group: (1) Voluntarily participate in the study, have obtained consent from their family members, and have signed an informed consent form; (2) Age between 10 to 18 years old; (3) Understand written language and are capable of completing questionnaires.
Exclusion criteria
Exclusion criteria: Patient Group: (1) History of substance dependence; history of mental disorders that meet the DSM-IV Axis I diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (3) Contraindications for MRI; (4) Pregnant or breastfeeding patients; (5) Family history or personal history of epilepsy. Healthy Control Group: (1) History of substance dependence; history of any mental disorders that meet the DSM-IV Axis I and II diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) History of loss of consciousness; (3) Positive family history of mental illness in two generations and three degrees; (4) History of taking antipsychotic or antidepressant medications; use of benzodiazepines or other central nervous system affecting drugs within one month before MRI; continuous medication treatment within the past 6 months; (5) Uncooperative in testing or unable to complete effectively; (6) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (7) Contraindications for MRI; (8) Pregnant or breastfeeding patients; (9) Color blindness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Children's Yale-Brown Obsessive-Compulsive Scale;resting-state cerebral functional magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Spence Children's Anxiety Scale;Family Accommodation Scale - Interviewer Rated;Children's Depression Inventory;Swanson, Nolan, and Pelham, Version IV;Cognitive Scale;Yale Global Tic Severity Scale;Obsessive-Compulsive Inventory - Child Version;The Adolescent Sleep Disturbance Questionnaire;Adolescent Self-Rating Life Events Check List;personal report of childhood abuse;Egna Minnen Barndoms Uppfostran;Eysenck Personality Questionnaire;Raven’s Progressive Matrices;Gastrointestinal Symptom Rating Scale;Short Form Leeds Dyspepsia Questionnaire; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed