Schizophrenia
Conditions
Interventions
Prospective observational study group:None
Case-control study group:None
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: Research One: 1.Meet the diagnostic criteria for schizophrenia as specified in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) through structured clinical interview (SCID-V); 2.Age between 16 to 70 years old; 3.Right-handed; 4.Han ethnicity. Research two: Schizophrenia Patients with Dysphagia Group: 1.Meet the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) through a structured clinical interview (SCID-V); 2.Aged between 16-70 years; 3.Right-handed; 4.Han Chinese ethnicity; 5.Eating Assessment Tool-10 (EAT-10) questionnaire score >=4. Healthy Control Group: 1.Physically healthy, with no disorders meeting the DSM-V Axis I diagnostic criteria upon SCID screening; 2.No psychotic symptoms with a score greater than "2"; no history of mental illness; 3.No current physical diseases; aged between 16-70 years; 4.No statistically significant differences in gender composition and education level compared to the schizophrenia patient group; 5.Right-handed; 6.Capable of cooperating to complete the assessment content of this project.
Exclusion criteria
Exclusion criteria: Research One: 1.History of substance dependence; history of mental disorders that meet the SCID Axis I diagnostic criteria; 2. History of brain trauma, epilepsy, or other organic brain diseases; 3.Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; 4.Non-cooperative individuals or those who cannot effectively complete the required tasks. 5.Neurogenic dysphagia and structural dysphagia. Research two: Schizophrenia Patients with Dysphagia Group: 1.History of substance dependence; history of mental disorders that meet the SCID Axis I diagnostic criteria; 2.History of brain trauma, epilepsy, or other organic brain diseases; 3.Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; 4.Non-cooperative individuals or those who cannot effectively complete the study; 5.Presence of neurogenic or structural dysphagia. Healthy Control Group: 1.History of substance dependence; history of mental disorders that meet the SCID Axis I diagnostic criteria; 2.History of brain trauma, epilepsy, or other organic brain diseases; 3.Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; 4.Non-cooperative individuals or those who cannot effectively complete the study; 5.Presence of neurogenic or structural dysphagia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of dysphagia in patients with schizophrenia;The correlation between schizophrenia and dysphagia;The clinical impact of dysphagia.;The pathological mechanisms of dysphagia in schizophrenia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depressive Symptoms Measured by the Hamilton Depression Scale;Anxiety Symptoms Measured by the Hamilton Anxiety Scale;Psychotic symptoms measured by the Positive and Negative Syndrome Scale for schizophrenia;Sleep conditions assessed by the Pittsburgh Sleep Quality Index;The Deficit Syndrome Schizophrenia Diagnostic Score Table classifies patients into deficit and non-deficit types;Cognitive Scale;Psychotic symptoms assessed by the Psychiatric Symptom Rating Scale;Interpersonal and social functioning assessed by the Personal and Social Performance Scale; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed