Postoperative delirium, perioperative cognitive dysfunction
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: a) the patient is at high risk of delirium; b) American Society of Anesthesiologists (ASA) grade I~III; c) Enrollment is ethical and must sign informed consent.
Exclusion criteria
Exclusion criteria: a) the patient has participated in other delirium intervention studies; b) disabling condition or visual impairment that prevents the patient from participating in this study; c) MMSE score < 24 points; d) Have used antipsychotic drugs before enrollment; e) Inability to participate in this study during the study cycle; f) Emergency surgery patients; g) Inability to communicate verbally due to deafness; h) the presence of other comorbidities that may be difficult to carry out drug intervention, such as myasthenia gravis, parkinsonism, schizophrenia, etc.; i) the need for a second surgery; j) Bring back the endotracheal tube into the ICU after surgery, because subsequent sedation and analgesia can affect the evaluation of delirium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium in the two groups of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in perioperative pain scores between the two groups;Comparison of anxiety conditions;Sleep improvements;Correlation between pain and postoperative cognitive function; | — |
Countries
China
Contacts
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine