Heart failure
Conditions
Interventions
Self-controlled trial group:Implant CRT,adjuste the pacemaker parameters to achieve optimal atrial electrical synchrony, electromechanical delay, and improvement left ventricular hemodynamics.
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 88 Years
Inclusion criteria
Inclusion criteria: The subject must be at least 18 years old, have chronic heart failure, be on guideline-directed medication, be classified as NYHA II-IV, have a sinus rhythm, a QRS duration of at least 130ms, and an LVEF of less than or equal to 35%.
Exclusion criteria
Exclusion criteria: (1) Second-degree, third-degree, complete atrioventricular block (2) ACS occurred within the past three months (3) currently pregnant or breastfeeding (4) expected survival with other diseases =1 year (5) currently participating in other clinical studies that may affect the results of this study (6) currently experiencing complications from CIED (such as wound infection, hematoma, electrode breakage)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventricular electrical synchrony: QRS duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electromechanical Excitation Time: the time to electromechanical excited;Left Ventricular Hemodynamics: Systolic Blood Pressure; | — |
Countries
China
Contacts
Public ContactSu Yangang
Zhongshan Hospital, Fudan University
Outcome results
None listed