None
Conditions
Interventions
experimental group:In-hospital phase feeding of in-hospital formula for new preterm infants, out-of-hospital phase feeding of out-of-hospital formula for new preterm infants
controlled group:In-hospital phase feeding of traditional preterm infants in-hospital formula, out-of-hospital phase feeding of traditional preterm infants out-of-hospital formula
Sponsors
Shanghai Children’s Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 1~7 days after birth; 2. Gestational age <34 weeks or birth weight <2000g; 3. Expected to be able to receive enteral feeding within the first 7 days after birth; 4. Daily breast milk intake not exceeding 20% of total feeding; 5. Have signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Infants with severe congenital malformations (such as digestive tract anomalies, diaphragmatic hernia, cyanotic congenital heart disease, etc.) or chromosomal abnormalities; 2. Infants who had surgery or required surgery prior to randomization; 3. Infants with severe intracranial hemorrhage (grade III or higher) or hydrocephalus; 4. Infants whose death risk within 72 hours of enrollment was judged by the investigator; 5. Infants whose participation was judged inappropriate by the investigator for other reasons; 6. Parents or guardians who refused to participate in the clinical trial; 7. Infants who had already participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anthropometry(Height, Weight, Head circumference);Incidence of EUGR;Z-score (weight for age, length for age, head circumference for age, weight for height); | — |
Secondary
| Measure | Time frame |
|---|---|
| Age at first attainment of complete enteral nutrition (150 ml/kg/d) and corrected gestational age;Length of hospitalisation;Feeding tolerance assessment (gastric residue =50% of previous intake (=2 times in 24 hours)); | — |
Countries
China
Contacts
Public ContactFei Bei
Shanghai Children’s Medical Center
Outcome results
None listed