Gallstones
Conditions
Interventions
Liver dysfunction group:None
Normal liver function group:None
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.ASA classification II-III; 2. Age 18-65 years old; 3.BMI:18.5-25; 4. Liver insufficiency is defined by Child-Pugh classification: patients with mild to moderate liver dysfunction. 5. Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1. Complicated with dysfunction of heart, lung and other important organs; 2. Patients with abnormal sleep, mental diseases, or a history of taking sedative and psychotropic drugs in the past 6 months; 3. Patients who are allergic to benzodiazepines; 4. Patients with hyperthyroidism or hypothyroidism in the past; 5. Patients with abnormal renal function 6. Patients judged unsuitable by other researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time from drug withdrawal to awakening; | — |
Secondary
| Measure | Time frame |
|---|---|
| Start administration until the time when eyelash reflex disappears;Time from drug withdrawal to tracheal extubation;PACU residence time;MAP, HR, SpO2 and body temperature at the time of entry (T0), induction, termination (T2), intubation (T3), maintenance and stop of pump injection (T4) and awakening (T5);Use of norepinephrine, atropine and esmolol during operation;Total amount of rimazolam used;Improved alertness/sedation score after awakening (MOAA/S);Ricker sedation-agitation scale (SAS); | — |
Countries
China
Contacts
Public ContactOUYANG Jie
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed