hematological malignancies
Conditions
Interventions
Case series :None
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. According to the 4th edition of the Diagnosis and Treatment Standards for Hematological Diseases and the 9th edition of Williams Hematology, patients who meet the criteria for lymphoma, myeloma, acute leukemia, or myelodysplastic syndrome. 2. With normal function of major organs, baseline indications and basic requirements for transplantation, patients who undergo autologous or allogeneic hematopoietic stem cell transplantation. 3. Aged between 16 and 70 years old; 4. ECOG score <=2; 5. Patients with an expected survival period of more than 6 months; 6. Voluntarily join this study, sign informed consent form, comply well, and receive follow-up visits on time.
Exclusion criteria
Exclusion criteria: 1.Pregnant women; Or a woman of childbearing age has a positive blood/urine pregnancy test, and the woman of childbearing age and her spouse are unwilling to use effective contraception during the clinical study period and for 6 months after the end of the clinical study; 2. Left ventricular ejection fraction (LVEF) <=45% on cardiac function assessment prior to transplantation or severe cardiac disease that precludes chemotherapy; 3. Seriously impaired renal function patients, calculated glomerular filtration rate (GFR) <15 ml/min×min2 by MDRD formula or long-term dialysis patients; 4. Patients who have had a serious cardiovascular adverse event within the past 6 months (acute myocardial infarction treated with percutaneous intervention or coronary artery bypass grafting).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine examination;liver function test;kidney function test;high-sensitivity troponin;N-terminal pro-brain natriuretic peptide;GDF-15;Electrocardiogram ;holter monitor;cardiac uhrasonography;cardiopulmonary exercise testing; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood glucose;serum lipid; | — |
Countries
China
Contacts
Public ContactMa Liangliang
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed