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DNA methylation as mechanism underlying the effect of mindfulness-based cognitive therapy on generalized anxiety disorder

DNA methylation as mechanism underlying the effect of mindfulness-based cognitive therapy on generalized anxiety disorder

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400093197
Enrollment
Unknown
Registered
2024-11-29
Start date
2024-09-13
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized anxiety disorder

Interventions

Test group:mindfulness-based cognitive therapy

Sponsors

Peking University Sixth Hospital (Institute of Mental Health )
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria 300.02 (F41.1) for GAD in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5); 2. The first seizure, and have not received systematic medication and psychotherapy; 3. HAMA score >= 14 points; 4. Age 18-65 years old; 5. Be able to understand and complete all aspects of treatment, and have no language communication barrier; 6.Enrollment criteria for the healthy control group: healthy subjects matched 1:1 according to age, gender, and educational level.

Exclusion criteria

Exclusion criteria: 1. Patients who have been or are currently diagnosed with the following mental disorders by DSM-5: organic mental disorder, schizophrenia, schizoaffective disorder, depressive disorder, bipolar disorder, other types of anxiety disorders; 2. Alcohol and drug dependence in the past 12 months; 3. Those with severe suicidal tendencies; 4. Suffering from a serious or unstable physical illness; 5. Pregnancy or breastfeeding.

Design outcomes

Primary

MeasureTime frame
Mindfulness;DNA methylation;anxiety;

Secondary

MeasureTime frame
depression;clinical global impression;childhood trauma;short form health survey;

Countries

China

Contacts

Public ContactHuang Xuebing

Peking University Sixth Hospital (Institute of Mental Health)

huangxuebing@bjmu.edu.cn+86 10 82805412

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026