Pain
Conditions
Interventions
Oliceridine combined with propofol:Oliceridine is administered intravenously before the surgery, followed by 2 mg/kg of propofol.
Oliceridine combined with Remimazolam:Oliceridine is administered intravenously before the surgery, followed by 0.25 mg/kg of remimazolam.
Sponsors
Women's Hospital of Nanjing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily participates in the study and signs the informed consent form, with the ability to adhere to the study protocol and requirements. 2. Aged 18 to 55 years. 3. Body mass index (BMI) between 18 and 25 kg/m2 (inclusive). 4. In a resting state, systolic blood pressure between 90 and 140 mmHg, diastolic blood pressure between 50 and 90 mmHg, heart rate between 50 and 100 beats per minute, and SpO2 > 95% under indoor conditions. 5. American Society of Anesthesiologists (ASA) physical status I or II, with no contraindications to intravenous anesthesia, and diagnosed by a gynecologist as needing hysteroscopic examination.
Exclusion criteria
Exclusion criteria: 1. Clinical history or physical examination indicating the presence of significant medical conditions (other than the study indications). 2. Significant abnormalities in vital signs or clinical laboratory test results. 3. Known allergy to any study drug. 4. Active gastrointestinal, respiratory, circulatory, neurological, or psychiatric conditions within 35 days prior to screening, deemed clinically significant by the investigator. 5. Clinically significant ECG abnormalities at screening, including QTcF >= 470 ms (female patients) on a 12-lead ECG.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ED90 of oliceridine for suppressing response to cervical dilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedative drug total dosage;Anesthesia induction time;Maintenance time of first dose;Times of body movement;Length of PACU stay;Time to full alertness;Procedure duration;Endoscopist satisfaction;Patient satisfaction;total sedation time;Pain score at the time of PACU discharge; | — |
Countries
China
Contacts
Public ContactYao Zhang
Women's Hospital of Nanjing Medical University
Outcome results
None listed