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Differences in the Induction of Remission and Safety between a Single Large-Dose Intramuscular Injection of Steroids and Short-Term Low-Dose Oral Steroid Therapy as Bridging Treatment: A Retrospective Cohort Study on Active Rheumatoid Arthritis

Differences in the Induction of Remission and Safety between a Single Large-Dose Intramuscular Injection of Steroids and Short-Term Low-Dose Oral Steroid Therapy as Bridging Treatment: A Retrospective Cohort Study on Active Rheumatoid Arthritis

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400093187
Enrollment
Unknown
Registered
2024-11-29
Start date
2024-12-01
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis has an insidious onset

Interventions

Single large-dose intramuscular steroid group:None
Short-term low-dose oral steroid group:None

Sponsors

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with RA in the included studies met the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for rheumatoid arthritis and were active (DAS28>2.6). From January 2020 to August 2024, he received a single high-dose corticosteroid injection (1ml of compound betamethasone injection) or a short-term low-dose hormone therapy in the outpatient department of rheumatology and immunology of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. The information such as gender, age, start and end time of treatment, and drug dosage were complete, and regular follow-up and follow-up data were complete.

Exclusion criteria

Exclusion criteria: Patients with RA with unclear diagnosis, absence of key information, incomplete follow-up data, and with factors that may interfere with the results of the study, e.g., patients with serious comorbidities, pregnant patients are excluded from the study.

Design outcomes

Primary

MeasureTime frame
Disease Remission Rate;

Secondary

MeasureTime frame
Disease Activity Score;Imaging Evaluation Indicators;Health Assessment Questionnaire;Liver and kidney function, Blood pressure, blood glucose, blood lipids, Body Mass Index;Bone Mineral Density (BMD);

Countries

China

Contacts

Public ContactLiu Honglei

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

hong-lei-liu@163.com+86 21 64370045

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026