Postoperative delirium
Conditions
Interventions
Neostigmine/glycopyrrolate:Neostigmine + glycopyrrolate
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age = 65 years old, male or female; 2) ASA grades I-III; 3) Undergoing major non-cardiac and non-neurosurgical procedures (thoracic, abdominal, urologic, orthopedic, and spine surgery) with an estimated surgical time = 1.5 hours; 4) Estimated discharge from the PACU to surgical wards after surgery and postoperative hospital stay = 2 days; 5) A clear understanding of the study and providing a written informed consent.
Exclusion criteria
Exclusion criteria: 1) Allergy to the drugs in the study; 2) Neostigmine contraindications (epilepsy, intestinal obstruction, urinary tract obstruction, asthma, glaucoma), paralysis, or neuromuscular diseases; 3) Severe liver insufficiency (Chil-Pugh grade C) or renal failure; 4) Long-term use of cholinesterase inhibitors, anticholinergic drugs or psychotropic drugs; 5) Inability to communicate effectively or refusal to participate in research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days with POD and percentage in postoperative hospital stay;Postoperative cognitive function;Peak CAM-S score and sum of CAM-S scores; | — |
Countries
China
Contacts
Public ContactPeng Ke
Department of Anesthesiology, The First Affiliated Hospital of Soochow University
Outcome results
None listed