CIPN
Conditions
Interventions
Control Group:Inject 6 ml sodium chloride
Experimental group:Injection 6 ml neurotropin
Sponsors
The Sixth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-80 years old; (2) Patients who have been diagnosed with colorectal cancer and have completed all chemotherapy treatment for at least 1 month; (3) Patients diagnosed with post-chemotherapy peripheral neuropathy by diagnostic criteria (>= grade 2); (4) Numbness score (VAS score) >=4 points; (5) Expected survival period >12 months; (6) without limb transfer; (7) No contraindications to the regimen of therapeutic drugs and neurotropin; (8) No long-term history of smoking or drinking; (9) Voluntarily participate in this experiment and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Accompanied by primary neuropathy; (2) previous diabetes, stroke, metabolic and other basic diseases; (3) There are cognitive disorders, serious infectious diseases, and abnormal coagulation function; (4) Patients with infection or other contraindications at the injection site; (5) Patients with neuroparesthesia due to nerve compression caused by tumor metastasis; (6) Severe depression and anxiety detected by psychological scale; (7) Patients with incomplete collection of evaluation index data affecting efficacy judgment; (8) Patients who voluntarily withdrew from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral nerve numbness VAS score;Sensory nerve conduction velocity of peripheral nerve; | — |
Secondary
| Measure | Time frame |
|---|---|
| EORTC QLQ-CIPN20, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire CIPN twenty-item scale;EORTC QLQ-C30, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, thirty-item scale;Karnofsky, KPS;PHQ-9, Patient Health Questionnaire-9;Adverse events;CSA, cross section area;Cross-sectional area variation rate (injury and the injury of the cross-sectional area ratio); | — |
Countries
China
Contacts
Public ContactWenjie Hu
The Sixth Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed