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A clinical observation on the postoperative analgesic effect of different local anesthetic mixture formula used for intercostal nerve block in patients undergoing video-assisted thoracoscopic lung lobectomy: a randomized, double-blind, controlled trial

A clinical observation on the postoperative analgesic effect of different local anesthetic mixture formula used for intercostal nerve block in patients undergoing video-assisted thoracoscopic lung lobectomy: a randomized, double-blind, controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400093132
Enrollment
Unknown
Registered
2024-11-28
Start date
2024-12-01
Completion date
Unknown
Last updated
2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute postoperative pain

Interventions

Group R1:Local Anesthetic Mixtures :Ropivacaine 0.15% (0.75%ropicaine 75mg + Epinephrine 50ug + 0.9% saline)
Group R2:Local Anesthetic Mixtures :Ropivacaine 0.15% (0.75%ropicaine 75mg + epinephrine 50 ug + dexmedetomidine 50 ug + 0.9% normal saline)
Group R3:Local Anesthetic Mixtures :Ropivacaine 0.15% (0.75%ropicaine 75mg + Epinephrine 50 mg + Ketorolac 30 mg + 0.9% normal saline)
Group R4:Local Anesthetic Mixtures :Ropivacaine 0.15% (0.75%ropicaine 75mg + epinephrine 50 ug + dexamethasone 5 mg + 0.9% saline)
Group R5:Local Anesthetic Mixtures :Ropivacaine 0.15% (0.75%ropicaine 75mg + epinephrine 50 ug + dexmedetomidine 50 ug + ketorolac 30 mg + 0.9% normal saline)
Group R6:Local Anesthetic Mixtures :Ropivacaine 0.15% (0.75%ropicaine 75mg + epinephrine 50 ug + dexmedetomidine 50 ug + dexamethasone 5 mg + ketorolac 30 mg + 0.9% saline)
Group R7:Local Anesthetic Mixtures :Ropivacaine 0.15% (0.75%ropicaine 75mg + epinephrine 50 ug + dexamethasone 5 mg + ketorolac 30 mg + 0.9% saline)

Sponsors

Guizhou Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy (wedge resection, segmentectomy, lobectomy); 2.Age >= 18 years old; 3.All subjects signed informed consent and cooperated with postoperative follow-up.

Exclusion criteria

Exclusion criteria: 1.Informed consent could not be provided; 2.Inability to understand written or spoken language; 3.ASA grade 4 or 5; 4.Planned ICU Admission; 5.Pneumonectomy.

Design outcomes

Primary

MeasureTime frame
NRS Pain Rating Scale;

Secondary

MeasureTime frame
The frequency of postoperative analgesia;Dose of opioids used after surgery;

Countries

China

Contacts

Public ContactKaiyu Fang

Guizhou Medical University, Guizhou Provincial People's Hospital

fangkaiyun@sina.cn+86 139 8553 3277

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026