lung injury
Conditions
Interventions
Gold Standard:Manual monitoring + esophageal pressure and/or electromyographic monitoring of the diaphragm through the esophageal tube
Index test:Mechanical power equivalent model
Patient-ventilator asynchrony diagnostic model
Risk prediction model for weaning risk
Sponsors
West China Tianfu Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Selection criteria for normal volunteers: (1) Age >= 18 years old, gender not limited; (2) There is no weight limit. At the time of enrollment, according to the BMI body mass index, it is divided into: lean, BMI index30; (3) Normal cardiopulmonary function (FEV1/FVC>70%, and FEV160cmH2O) (5) The body's motor function is sound; (6) No history of neurological and respiratory diseases; (7) Sign the informed consent form and be willing to participate in the trial. Inclusion criteria for ICU patients: (1) Age >= 18 years old, gender not limited; (2) There is no weight limit. At the time of enrollment, subgroups were divided based on BMI: lean, BMI30; (3) Invasive mechanical ventilation status (mechanical ventilation through tracheal intubation or tracheotomy); According to the respiratory ventilation mode, subgroups are divided into low tidal volume ventilation and non low tidal volume ventilation. (4) The authorized person/patient signs an informed consent form and is willing to participate in the trial.
Exclusion criteria
Exclusion criteria: Exclusion criteria for normal volunteers: (1) Pregnancy status; (2) Chest deformity. Exclusion criteria for ICU patients: (1) Pregnancy status; (2) Plan to withdraw the aircraft within 24 hours; (3) Severe respiratory center depression, high paraplegia, and neuromuscular disorders; (4) Esophageal obstruction, esophageal perforation, severe esophageal variceal bleeding, esophageal, gastric or lung surgery, diaphragmatic hernia, thoracic deformity; (5) Bronchopleural fistula, pneumothorax, mediastinal emphysema, thoracic drainage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient-ventilator asynchrony; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity ;Specificity; | — |
Countries
China
Contacts
Public ContactYan Kang
West China Tianfu Hospital of Sichuan University
Outcome results
None listed