Depressive Disorders
Conditions
Interventions
Depression Disorder Patients Undergoing Electroconvulsive Therapy Group:None
Depression Disorder Patients on Pharmacological Treatment Group:None
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 50 Years
Inclusion criteria
Inclusion criteria: Depressive Disorder Patients (Electroconvulsive Therapy Group): (1) Meet the diagnostic criteria for depression through structured clinical interview (SCID-V); (2) Age between 14 to 50 years old, right-handed, Han ethnicity; (3) Score of over 20 on the Hamilton Depression Scale (HAMD-24); (4) IQ > 90 (Wechsler Intelligence Scale); (5) Receive electroconvulsive therapy. Depressive Disorder Patients (Pharmacological Treatment Group): (1) Meet the diagnostic criteria for depression through structured clinical interview (SCID-V); (2) Age between 14 to 50 years old, right-handed, Han ethnicity; (3) Score of over 20 on the Hamilton Depression Scale (HAMD-24); (4) IQ > 90 (Wechsler Intelligence Scale); (5) Receive pharmacological treatment. Healthy Control Group: (1) In good health, with no disorders meeting the DSM-5 Axis I diagnostic criteria upon SCID screening; (2) No history of mental illness; (3) No current severe physical diseases; (4) Age between 14 to 50 years old, right-handed, Han ethnicity; (5) Capable of cooperating to complete the project assessments; (6) Matched with the patient group in terms of age, gender, and education level; (7) IQ > 90 (Wechsler Intelligence Scale); (8) Intact social functioning (able to work or study normally, not retired due to illness), with full capacity for action and responsibility.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for All Patients: (1) History of substance dependence; history of mental disorders that meet the SCID Axis I diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (3) Contraindications for MRI or MECT; (4) Pregnant or breastfeeding patients; (5) Family history or personal history of epilepsy; (6) Patients receiving other physical treatments during MECT treatment. Exclusion Criteria for Healthy Controls: (1) History of substance dependence; history of any mental disorders that meet the SCID Axis I or II diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) History of loss of consciousness; (3) Positive family history of mental illness in two generations and three degrees; (4) History of taking antipsychotic or antidepressant medications; use of benzodiazepines or other central nervous system affecting drugs within one month before MRI; continuous medication treatment within the past 6 months; (5) Uncooperative in testing or unable to effectively complete tests; (6) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (7) Contraindications for MRI or MECT; (8) Pregnant or breastfeeding patients; (9) Color blindness; (10) Patients receiving other physical treatments during MECT treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 24-Item Hamilton Rating Scale measures the symptoms of depression;Changes in brain structure and function measured by magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Hamilton Anxiety Scale measures the symptoms of anxiety;The Positive and Negative Syndrome Scale measures the positive and negative symptoms;The Columbia Suicide Severity Rating Scale measures suicidal ideation and behavior.;The Hypomania Check List measures the tendencies towards hypomania;The Pittsburgh Sleep Quality Index measures the quality of sleep;The Life Events Scale measures the occurrence of psychosocial stressors;The Childhood Trauma Questionnaire measures the experiences of childhood development;The Snaith-Hamilton Pleasure Scale measures the levels of anhedonia;The Sheehan Disability Scale assesses the social functioning of patients;The Ottawa Self-injury Inventory measures self-injurious behaviors;The Self-Rating Depression Scale measures the symptoms of depression;The Self-Rating Anxiety Scale measures the symptoms of anxiety.;Cognitive function;ECT treatment parameters;Pharmacological Treatment Plan; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed