Gastrointestinal disorders
Conditions
Interventions
Group C:sedation using ciprofol
Group M1:sedation using a mixture of ciprofol and etomidate in a volume-to-volume ratio of 1:1
Group M2:sedation using a mixture of ciprofol and etomidate in a volume-to-volume ratio of 2:1
Sponsors
Zibo Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old, gender is not limited; 2. Planned to undergo painless digestive endoscopy; 3. ASA Grading I–II; 4. Body mass index (BMI) >=18 and < 30 kg/m^2 5. Patient is willing to participate in this study and sign a written informed consent form
Exclusion criteria
Exclusion criteria: 1. Known allergy to any of the study drugs, allergy to eggs or soy products; 2. Uncontrolled or poorly controlled hypertension (SBP>=180 mmHg and/or DBP>=110 mmHg), or hypotension (SBP= 3); 4. Severe hepatic dysfunction (Child-PughB or Class C), renal insufficiency (serum creatinine >2 mg/dL), or cardiac dysfunction (NYHA Class III and IV); 5. Adrenal insufficiency (serum cortisol < 3 ug/dL); 6. Patients with epilepsy, neurocognitive or psychiatric disorders; 7. Taking sedatives or hypnotics in the past 3 days; 8. History of general anesthesia within the past 7 days; 9. Pregnancy or lactation; 10. Have a history of alcohol or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composite incidence of various adverse events (AEs); | — |
Secondary
| Measure | Time frame |
|---|---|
| success rate of sedation;induction time;awake time;recovery time;patient satisfaction;vital signsvital signs; | — |
Countries
China
Contacts
Public ContactJiguo Si
Zibo Central Hospital
Outcome results
None listed