Diminished ovarian reserve
Conditions
Interventions
Routine treatment group:Hormone supplement therapy
Conventional treatment group + probiotics vaginal medication group:Hormone supplementation + probiotics vaginal medication group
Healthy control group:None
Sponsors
Ganzhou People 's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 42 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the normal control group (Group C): (1) women of childbearing age (20-42 years old) with regular menstrual cycles; normal ovarian function; (2) No history of sexual life, vaginal douching and medication within 3 days before the examination; (3) There were no obvious abnormalities in vaginal discharge, cervical cancer prevention screening and gynecological color ultrasound examination; (4) Those who have no other chronic underlying diseases. 2. Inclusion criteria for the group (Group D) of reduced ovarian reserve: (1) females of childbearing age (20-42 years old); (2) AMH<1.1ng/ml; both ovarian AFCs< 5-7; and/or basal blood FSH = 10 IU/L for two consecutive menstrual cycles; (3) No history of sexual life, vaginal douching and medication within 3 days before the examination; (4) There is no history of allergies to probiotics.
Exclusion criteria
Exclusion criteria: 1. No sexual history; 2. The patient is in the menstrual period, pregnancy, lactation and menopause; 3. Combined with severe heart, lung, liver, kidney dysfunction, malignant tumors and metabolic immunity-related diseases; 4. Suffering from other gynecological organic diseases; 5. Systemic antibiotics or sex hormone intervention in the past 1 month; 6. Loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of eggs obtained by DOR patients in intervention group and non-intervention group;Ovarian reserve of patients with DOR in intervention group and non-intervention group;The number of high-quality embryos in the intervention group and the non-intervention group of patients with DOR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vaginal microecology in DOR patients and healthy controls;Clinical symptoms of patients with DOR in intervention group and non-intervention group;Pregnancy outcomes of patients with DOR in intervention group and non-intervention group; | — |
Countries
China
Contacts
Public ContactLiu Yan
Ganzhou People 's Hospital
Outcome results
None listed