Gastrointestinal diseases
Conditions
Interventions
Control group:0.1ug/kg sufentanil + 1.5mg/kg propofol
Magnesium sulfate group:40mg/kg magnesium sulfate+ 1.5mg/kg propofol
Sponsors
Yancheng First People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients aged 65 years or older; 2.BMI between 18.5-28 kg/m2; 3.ASA grade I-III patients undergoing gastroenteroscopy;
Exclusion criteria
Exclusion criteria: 1.Patients who were allergic to sedative/anesthetic drugs such as sufentanil and propofol or had a history of severe allergic reactions; 2.Patients who had contraindications to endoscopy or refused anesthesia; 3.Patients who were unaccompanied by family members; 4.Uncontrolled severe hypertension (SBP>= 180mmHg, DBP>= 110mmHg); 5.Patients with a recent acute respiratory infection, an acute exacerbation of asthma, an acute exacerbation of COPD, or preoperative hypoxemia; 6.Acute coronary syndrome, severe arrhythmia, or heart failure; 7.Massive hemoptysis during the active phase; 8.Severe anemia (Hb < 6g/dL); 9.Patients with mental health disorders and cognitive dysfunction who cannot communicate effectively. 10.Have a history of psychotropic and narcotic drug abuse; 11.Liver dysfunction (Child-Pugh grade C or higher); renal dysfunction (CKD stage 3 or higher); 12.Pregnant or lactating women; 13.Acute upper gastrointestinal bleeding accompanied by shock, pyloric obstruction, achalasia of the cardia, gastric emptying disorders, and a history of upper gastrointestinal surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| 15-item quality of recovery scale;Incidence of hypotension;Incidence of bradycardia;Incidence of PONV;Visual analogue scale of pain;Propofol dosage;Magnesium ion concentration;Recovery time;PACU stay duration;The satisfaction of gastroenterologist;The satisfaction of patients; | — |
Countries
China
Contacts
Public ContactLiu Xiang
Yancheng First People's Hospital
Outcome results
None listed