Specific Disorders: Autism Spectrum Disorders Symptoms: Social impairment, communication disorders, narrow interests and stereotyped behaviors are the main symptoms
Conditions
Interventions
probiotic group:Receive probiotic (=30 billion CFU) daily
Control group:placebo
Sponsors
Hebei Children’s Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1.Age 2-12 years; 2.Children diagnosed with autism spectrum disorder; 3.Signed informed consent;
Exclusion criteria
Exclusion criteria: 1.Have a genetic disorder: trisomy 21, tuner syndrome, Down syndrome, fragile X chromosome syndrome, etc. 2.Exclusion of cerebral palsy, structural brain abnormalities, seizures, tuberous sclerosis, schizophrenia, depression; 3.Exclusion of patients with clinically significant anemia, metabolic disorders; 4.Use of all types of antifungal drugs, antibiotic drugs, immunosuppressive drugs, antipsychotics and other probiotics and prebiotics in the last month; 5.Other unstable or serious diseases of the heart, lungs, liver, kidneys, or hematopoietic system (including unstable angina, uncontrolled asthma, severe allergies, active gastric bleeding, and acute leukemia); 6.Children judged by the investigator to be unsuitable for study participation;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| oral microoganism;neurotransmitter;blood routine;urine-RT;CK;neuron specific enolase;total lymphocyte;pathogen testing;fecal flora; | — |
Countries
China
Contacts
Public Contactwang xia
Hebei Children’s Hospital
Outcome results
None listed