perioperative neurocognitive disorders
Conditions
Interventions
Group A (routine care group):routine care intraoperative
Group B(aggressive warming group):inflatable heating blankets
Sponsors
Department of Anesthesiology,
Xuzhou Central Hospital, Xuzhou 221009, Jiangsu, China.
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1Age 65-90 years; 2ASA I-III; 3Patients with preoperative MMSE score >23 and without fever; 4Planned Total hip arthroplasty under general anesthesia; 5Patients volunteered to be tested and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1Pre-operative cognitive dysfunction, mental or psychological diseases; 2Serious abnormalities of liver and kidney function; 3Diabetic patients with diabetes mellitus complications; 4Unstable angina pectoris, myocardial infarction, and any cerebrovascular accidents such as stroke, or transient ischaemic attack (TIA) within 3 months; 5Blood pressure = 180/110 mm Hg at preoperative visit; 6 Those who are determined/suspected to have abused or long-term application of narcotic sedative analgesics; 7Those who have taken hormones or other immunosuppressive drugs for >10 days within 6months or have a history of adrenocortical suppression or have an immune system disorder; 8Those who suffer from hyper- or hypothyroidism, rheumatism and other diseases; 9Patients with serious infectious diseases that cause elevated body temperature; 10Those who will be operated again within 3 months; 11Patients participating in other studies within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of dNCR at 7 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of POCD at 1 and 3 months ;Peripheral blood levels of L-6, S-100ß, Aß, Tau, pTau; | — |
Countries
China
Contacts
Public ContactKai Wang
Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou 221009, Jiangsu, China.
Outcome results
None listed