cerebral hemorrhage
Conditions
Interventions
The time from onset to initiation of hypotension is 0-2 hours:none
The time from onset to initiation of hypotension is 2-4 hours:none
The time from onset to initiation of hypotension is 4-6 hours:none
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age >18 years old; 2) Spontaneous cerebral parenchymal hemorrhage confirmed by emergency CT that can be treated with hypotensive therapy within 6 hours of onset; 3) Baseline systolic blood pressure persistence >150mmHg; 4) Baseline GCS score >5; 5) Patients or their immediate family members can cooperate with informed consent.
Exclusion criteria
Exclusion criteria: 1) The time of onset is unknown; 2) There are definite diseases that cannot strengthen hypotension, such as severe intracranial and extracranial arterial stenosis (>75%), renal insufficiency, etc.; 3) There is secondary cerebral hemorrhage, such as hemorrhage secondary to brain structural abnormalities (AVM, moyamoya disease, aneurysm, cavernous hemangioma, brain tumor, etc.); 4) Cerebral hemorrhage caused by coagulation dysfunction, including blood system lesions and coagulation dysfunction caused by the use of anticoagulant drugs; 5) Cerebral hemorrhage after thrombolysis; 6) History of stroke within 30 days; 7) Serious medical diseases such as liver and kidney insufficiency, advanced tumors, heart failure, respiratory failure, and severe dementia; 8) Patients with contraindications to nicardipine and urapidil (severe aortic stenosis, severe mitral stenosis, obstructive hypertrophic cardiomyopathy, acute cardiac insufficiency, severe myocardial infarction, pulmonary embolism, etc.); Or allergic to nicardipine or uradil; 9) Baseline mRS Score >2; 10) Neurosurgical intervention is considered in the short term.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional outcome at 90 days of onset; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hematoma enlargement 24 hours after onset;NIHSS score;Ordinal analysis of mRS Scores at 90 days after onset;90-day ADL of daily living; | — |
Countries
China
Contacts
Public ContactJianhui Fu
Department of Neurology, Huashan Hospital, Fudan University
Outcome results
None listed