Postoperative delirium
Conditions
Interventions
Group L:Fluid restriction, head-high-feet-low position, and the use of vasodilators or diuretics were used to reduce CVP, resulting in a CVP of <5 cmH2O in patients in group L before the start of hepa
Group N:No CVP-lowering strategy was adopted, fluid infusion was performed according to the principles of rehydration, and CVP was maintained at 5-12 cmH2O intraoperatively.
Sponsors
Hainan General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.ASA ?~?; 2.Child-Pugh A-B; 3.Age 18-65 years 4.Patients undergoing elective laparoscopic hepatectomy; 5.Patients who are able to understand the process and methods of this study and who volunteer to participate in this study.
Exclusion criteria
Exclusion criteria: 1.Those who refused to participate in this study; 2. Those who have contraindications to general anesthesia or have had previous accidents with general anesthesia; 3.Patients with known allergies or contraindications to any of the drugs used in the study; 4.Hemoglobin (Hb) 35 kg/m^2 or 178 µmol/L); 7. Patients with uncontrolled hypertension, hypotension and diabetes mellitus; 8.Patients with a previous history of schizophrenia, epilepsy or Parkinson's disease; 9. Patients with visual, auditory, speech, or other impairments that impede communication and delirium assessment; 10.Patients with a history of cerebral infarction, cerebrovascular malformation, traumatic brain injury, or neurosurgery; 11. Patients with severe heart disease, including active coronary artery disease, severe valvular stenosis, and hypertrophic obstructive cardiomyopathy; 12. Patients who are pregnant or breastfeeding; 13. Patients with a history of alcoholism or drug dependence; 14. Patients abusing or chronically applying anesthetic, sedative, analgesic drugs; 15.Patients who have participated in other studies in the last 2 months; 16.Subjects with factors that, in the opinion of other investigators, make participation in this trial inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral oxygen saturation;Jugular venous oxygen saturation (SjvO2), cerebral oxygen uptake rate (CERO2), cerebral blood flow/cerebral metabolism of oxygen ratio (CBF/CMRO), arterial blood lactate leve;Intraoperative bleeding and urine output;Perioperative blood creatinine (Scr), blood urea nitrogen (BUN);Rates of postoperative complications, ICU admissions, ICU stays, and total length of stay within 7 days after surgery; | — |
Countries
China
Contacts
Public ContactDuozhi Wu
Hainan General Hospital
Outcome results
None listed