idiopathic membranous nephropathy
Conditions
Interventions
ARA positive group:NA
ARA negative group:NA
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of pMN; 2. Over 18 years of age; 3. eGFR>40ml/min; 4. Use RTX to therapy.
Exclusion criteria
Exclusion criteria: 1.Patients with secondary MN; 2.Patients with lymphoma, SLE, RA, hepatitis B, hepatitis C, AIDS and other diseases; 3.Allergic to RTX or mouse protein; 4.Patients with severe active infection; 5.Patients with severely impaired immune response (such as hypogammaglobulinemia, severe decreased CD4 or CD8 cell counts); 6.Patients with severe heart failure (NYHA grade ?); 7.Use of Glucocorticoid, CNI or cyclophosphamide within 4 months; 8.Pregnant and breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| renal function;adverse event;Anti-rituximab antibodies titer;Rituximab drug concentration;B lymphocyte count;Anti-PA2R antibody titer;Random urinary total protein creatinine ratio, UPCR; | — |
Countries
China
Contacts
Public ContactQijun Wan
Shenzhen Second People's Hospital
Outcome results
None listed