Gastric ulcer, stomach pain and other diseases requiring gastroscopy
Conditions
Interventions
Nalbuphine group N2:Nalbuphine 0.3mg/kg
Nalbuphine group N1:Nalbuphine 0.15mg/kg
Sponsors
Affiliated Qingyuan Hospital, Guangzhou Medical University,Qingyuan People's Hospital;
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 to 65 years undergoing gastroscopy with general anesthesia; 2.ASA grade I-II; 3.BMI more than 28 kg/m2; 4.Able to sign the informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients with known history of anaphylaxis to the study plan medication; 2.Irregular control or history of severe hypertension; 3.Severe coronary artery disease, psychosis, chronic pain, pregnancy or planned pregnancy within 3 months, seizures, increased intracranial pressure; 4.Recent (within 3 days) history of use of analgesics, history of drug abuse or use of central nervous system drugs within 6 months; 5.Patients with significant respiratory depression, acute or severe asthma; 6.Known or suspected gastrointestinal obstruction (including paralytic ileus) ;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 of propofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;SPO2;Total time of endoscopy,;Time to resuscitation;Length of stay in resuscitation room;Satisfaction of patient;Satisfaction of endoscopist;Incidence of sedation-related adverse events;The first time of use vasoactive drugs;The first time need for airway intervention; | — |
Countries
China
Contacts
Public ContactHuang Yizhou
Affiliated Qingyuan Hospital, Guangzhou Medical University,Qingyuan People's Hospital;
Outcome results
None listed