Infertility and assisted reproductive technology
Conditions
Interventions
Gold Standard:Traditional invasive biopsy of human embryos
Index test:non-invasive chromosome screening(NICS) based on spent culture medium
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Either or both couple with chromosomal structural rearrangements(such as reciprocal translocations, Robertsonian translocations, inversions, etc.), an indication for PGT-SR, who intend to undergo PGT-SR 2.Volunteer to participants in the study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications for assisted reproductive technology (ART) treatment. 2. Chromosomal rearrangements involving small segments, where the fragments of unbalanced embryos <4Mb. 3. Other situations deemed unsuitable for participation in this study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concordance (abnormalities related to parental rearrangement); | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal contamination rate of culture medium;Detection failure rate of culture medium; | — |
Countries
China
Contacts
Public ContactShen Jiandong
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital)
Outcome results
None listed