A randomized controlled trial of endodontic treatment using sonic-activated irrigation and passive ultrasonic irrigation to evaluate healing in chronic apical periodontitis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400093017

Enrollment

Unknown

Registered

2024-11-27

Start date

2024-12-01

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic apical periodontitis

Interventions

Test group:Sonic-Activated Irrigation

Control group:Passive Ultrasonic Irrigation

Eligibility

Sex/Gender

All

Age

18 Years to 59 Years

Inclusion criteria

Inclusion criteria: 1.Agree to participate in this study and provide informed consent; 2.Age 18-59 years at the time of enrolment; 3.At least one permanent tooth diagnosed with chronic periapical periodontitis at root development stage of Nolla10th; 4.Able to follow up on schedule.

Exclusion criteria

Exclusion criteria: 1.Allergies to any medications or materials necessary to complete the procedures; 2.Non-restorable teeth, teeth with severe defects, or teeth that need to be extracted due to orthodontic treatment; 3.Teeth with root canal treatment or vital pulp therapy; 4.Teeth with canal calcification or root canal instrument separation; 5.Teeth with root fracture or vertical root fracture; 6.Tooth with internal or external root resorption; 7.Patients with periodontitis; 8.Patients with orthodontic treatment; 9.Presence of dental phobia; 10.Women who are pregnant; 11.Patients who have taken medications that affect central nervous system, such as tricyclic antidepressant; 12.Patients who have taken medications that affect immune response, such as glucocorticoid or cyclosporin; 13.Patients after radiotherapy of tumor head and neck; 14.Patients who have taken medications that affect curative effect, such as bisphosphonates; 15.Patients with serious systemic diseases that can affect curative effect; 16.Participation in other clinical studies within the past several weeks; 17.Patients who are deemed unsuitable to participate in the study by investigators.

Design outcomes

Primary

Measure	Time frame
therapeutic effect;	—

Secondary

Measure	Time frame
postoperative pain;Cone Beam Computed Tomography Periapical Index Scores (CBCTPAI);The sizes of periapical lesions;	—

Countries

China

Contacts

Public ContactYuee Liang

Nanfang Hospital, Southern Medical University

869624720@qq.com+86 20 6278 2149

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026