Success rate of anesthesia induction
Conditions
Interventions
Fospropofol disodium group:Induction of anaesthesia with disodium fospropofol
Etomidate group:Etomidate induction of anaesthesia
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients who are planning to undergo coronary artery bypass grafting, valve replacement, or elective thoracic major vascular surgery; 2.Age 18-65, no gender limit; 3.18kg/m2<BMI<30kg/m2; 4.NYHA heart function class II-IV; 5.ASA classification III or above;
Exclusion criteria
Exclusion criteria: 1.Severe cardiovascular instability (acute heart failure, myocardial infarction, etc.); 2.Poorly controlled hypertension; 3.Patients with liver and renal dysfunction; 4.Allergic to fospropofol disodium or etomidate; 5.Participated in another study within 4 weeks before the current trial; 6.Drug and alcohol abuse patients; 7.Pregnant and lactating patients; 8.Patients using QT interval prolongation drugs in the 3 months prior to surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of anesthesia induction 5 minutes after sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time from intubation to anesthesia maintenance;Blood pressure and the incidence of hypertension, hypotension, bradycardia, and tachycardia;BIS value;Output volume, peripheral circulatory resistance, stroke volume variability;Frequency and total dose of vasoactive drugs;Incidence of adverse reactions: paresthesia during induction, injection pain, muscle tremor, awareness during surgery;Adverse reactions during the induction period: paresthesia, injection pain, muscle tremor, etc.; | — |
Countries
China
Contacts
Public ContactYaomin Zhu
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed