Prolactinoma
Conditions
Interventions
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosis of prolactinoma: Clinical manifestations: the main manifestations of women are irregular menstruation (thin menstruation, irregular menstruation, amenorrhea, etc.), galactorrhea, repeated abortion and infertility, etc. The main manifestations of male prolactinoma are decreased libido, impotence, male mammary gland development, reduced sperm count, and even genital atrophy. Laboratory test: Prolactin level is generally greater than 150ng/ml; Imaging examination: pituitary enhanced MRI examination, etc; 2.The pituitary enhanced MRI showed clear tumor boundaries, microadenoma or non-invasive macroadenoma; 3.Age: 15-80 years old; 4.Gender: no limitation; 5.Karnofsky(KPS) scale >=70; 6.No counter-surgical evidence
Exclusion criteria
Exclusion criteria: 1.Patients with prolactinoma who have received gamma knife treatment; 2.Invasive prolactinoma: the tumor invades the surrounding tissue structures, such as the cavernous sinus, sphenoid sinus, sieve sinus, and triventricle; From the imaging evaluation, Knosp grade 3 and 4; 3.Patients who have been treated with drugs other than DAs targeting prolactinoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prolactin remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor recurrence;Tumor volume;Clinical symptoms;Pituitary hormone levels;Surgical complications;Mental symptoms;Economical burden;QALYs, Quality-adjusted life years;Health-related quality of life;Additional treatment; | — |
Countries
China
Contacts
Public ContactZhebao Wu
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed