Fracture of bone
Conditions
Interventions
Intravenous administration group:Esketamine was administered intravenously
Nerve block group:Esmketamine was injected into the perineural area as a local anesthetic adjuvant
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who need elective upper limb fracture surgery under general anesthesia; 2. Aged 18-65 years old; 3. Body mass index (BMI) 18-27 kg/m^2; 4. ASA I-III grade;
Exclusion criteria
Exclusion criteria: 1. Contraindications of nerve block: coagulopathy, infection at the puncture site, deformity or tumor; 2. Combined with chronic pain or long-term use of analgesic drugs; 3. Combined with central nervous system disease or psychosis; 4. Local anesthetic drug allergy; 5. Pregnant or lactating women; 6. Previous heart failure or arrhythmia; Uncontrolled hypertension; Diabetes mellitus with poor glycemic control; Liver and kidney dysfunction; 7. Unable to communicate proficiently in Chinese;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of rebound tenderness after nerve block; | — |
Secondary
| Measure | Time frame |
|---|---|
| The NRS scores ;Heart rate;The occurrence of adverse reactions ;Quality of recovery scale (QoR-15) score; pain sensitivity questionnaire score;consumption of remifentanil;Mean blood pressure; | — |
Countries
China
Contacts
Public ContactXuesheng Liu
The First Afliated Hospital of Anhui Medical University
Outcome results
None listed