Disease of respiratory system
Conditions
Interventions
Control group :equal volume of physiological saline
esketamine group:intravenous infusion of 0.2 mg/kg esketamine
Sponsors
Jiangmen Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) The American Society of Anesthesiologists classifies it as Grade I-II; (2) Those who plan to undergo fiberoptic bronchoscopy under general anesthesia without intubation; (3) There are clear indications for painless fiberoptic bronchoscopy examination; (4) Those who voluntarily participate in the research and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Preoperative oxygen inhalation with blood oxygen saturation less than 90%; (2) The patient has a history of depression or taking antidepressants; (3) Patients with neurological and psychiatric disorders or a history of drug abuse; (4) The patient's cooperation is poor and they are unable to cooperate with the scale evaluation; (5) After examination, the patient has abnormal liver and kidney function; (6) The patient has a history of thyroid dysfunction; (7) Patients who experience serious adverse reactions during bronchoscopy examination; (8) Severe hypertension, intraocular pressure, or intracranial pressure, with severe cardiovascular disease; (9) Individuals who are allergic to the drugs used in the research protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ramsay Sedation Scale, RSS; | — |
Secondary
| Measure | Time frame |
|---|---|
| mean arterial pressure, MAP;heart rate, HR;arterial oxygen saturation, SpO2;Quality of Recovery-15, QoR-15; | — |
Countries
China
Contacts
Public ContactShijie Deng
Jiangmen Central Hospital
Outcome results
None listed