None
Conditions
Interventions
Ariyan group:The intervention phase totaled 24h, with medication administered every 8 hours based on grouping results. After subjects entered the preoperative preparation room on the day of surgery, p
Placebo group:The intervention phase lasted 24 h, and the drugs were administered every 8 h according to the grouping results. After subjects entered the preoperative preparation room on the day of su
Sponsors
Zhongshan Hospital of Fudan University, Xiamen Branch
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: a. Age: 18-70 years old b, Type of surgery: laparoscopic total hysterectomy c, ASA classification: Grade I-III d, able to use pain scale, QoR-15 scale, sleep quality scale and operate intravenous PCA device e, Understanding and willingness to participate in the trial, signed informed consent by themselves or their immediate family members
Exclusion criteria
Exclusion criteria: a. Clear preoperative allergy or hypersensitivity to test drugs (acetaminophen and mannitol); b. Impairment of vital organs such as impaired liver function (transaminases = twice the upper limit), patients with active liver disease, chronic hepatitis, cirrhosis of the liver, chronic kidney disease, renal insufficiency (creatinine = 2.0 mg/dl), chronic malnutrition, and known or suspected history of alcohol or drug abuse; c. Pregnant or lactating patients; d. Those who require preoperative sleep aids with tranquilizers; e. severe hypovolemia (due to dehydration or blood loss), glucose-6-phosphatase dehydrogenase deficiency; f. The presence of trauma, infection or dermatitis at the puncture site that precludes nerve block operation; g. patients with preoperative cognitive dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain visual analog score;QoR-15;Sleep quality score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative opioid consumption;rescue analgesia rate;Incidence of anesthesia-related adverse reactions;Antiemetic rescue rate; | — |
Countries
China
Contacts
Public ContactGuiting Li
Zhongshan Hospital of Fudan University, Xiamen Branch
Outcome results
None listed